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You are watching: What does clinical correlation recommended mean


In a mind MRI report, the complying with words regularly appear: “clinical correlation is recommended”. This words represent that poor clinical info was provided, or the an unforeseen finding ~ above the MRI need to be assessed clinically. “Clinical correlation is recommended” is less typical in a report around a solitary gene or simple gene panel. This is since the very act of bespeak the test conveys lot of what is important about the clinical situation, and only rarely is additional information needed.

Genetics labs are moving into brand-new territory together they adopt next-generation genomic sequencing. When moving beyond solitary gene exam and straightforward panels, more clinical correlation is needed. The intricacy of translate becomes similar to a mind MRI, only an ext so.

In one exome, countless variants are found. Even after comparing come other household members, and also using estimates of variant pathogenicity, numerous genes should be considered. Periodically clinical correlation can be as basic as making use of the vital clinical finding, assuming the you know which finding is key. However sometimes the situation is an ext complicated: variants are uncovered in a gene the hadn"t been considered clinically, or two genes are needed to explain the clinical picture, and an ext clinical correlation is needed.

For brain MRI scans, this clinical correlation is institutionalized as neuroradiology rounds held several times a main by many neurology inpatient services. Just how should the analogous clinical correlation because that genomic translate be structured?

The core principle of clinical correlation have to be that comprehensive information about the patient"s findings, the phenotype, is merged with in-depth information in the annotated different table, the genotype. Due to the fact that this is done in the more comprehensive context that considering all known phenotypes, the an outcome is a “genome–phenome” analysis.

In what venue have to the “aha” of this clinical correlation occur? each venue has plusses and minuses:

Hybrid: Genome and also phenome expertise can be joined by having actually meetings the clinical and also genomic experts comparable to neuroradiology rounds or tumor boards. This hybrid venue involves delays and overhead of huge teams, but unites deep expertise in both genome and phenome. The efficacy the the process would count on the quality and efficiency that this communication between clinical and also genomic experts.

Each of this models involves considerable training or overhead to combine genome and phenome information. However, the capability to do so is greatly promoted by software application tools that aid combine genomic and also clinical expertise. Such software application has developed in a stepwise process and is currently in use amongst clinicians and also lab experts:

Communication boosts as its power is demonstrated: once clinicians are component of the process of genome interpretation, they watch the prestige of giving robust phenotypic information and helping curate information about known phenotypes. See the difference between “garbage in, garbage out” and “quality in, quality out” is precious a thousands exhortations.

As labs go v the social shift from single gene tests to genomic analysis, the is an essential to focus on the procedure of clinical correlation, the venue in which the is done, and the devices that can aid get clinical and genomic experts “on the very same page”.


Funding source

Some of the work on i m sorry this commentary is based has actually been supported by NIH grants and contracts come the author (National Library of medicine HHSN276201000026C and also 5R44LM011585, and National human being Genome research study Institute 1R43HG006974 and 2R42HG006974).


Conflict that interest

The writer is to work by SimulConsult, i m sorry produces genome evaluation software.

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Segal M, Leber S “The affect of computer resources on son neurology” in Swaiman KF et al. “Pediatric Neurology: Principles and Practice”, fifth edition, Mosby, 2012.