Antidepressants prefer citalopram and also sertraline can help people conquer depression. At the same time, they have the right to have adverse reactions when blended with other drugs. World who room prescribed medication for depression should be careful about which other substances they combine with their meds. Over there are countless drugs that don’t mix with antidepressants. If you, or who you know, may be battling v addiction of prescription medication or entertain drugs, contact our AspenRidge restore Centers in ft Collins and also Lakewood (Denver Metro) for substance abuse treatment in Colorado.

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4 Drugs that Don’t Mix through Antidepressants

When your physician prescribes friend anti-depression pills, castle should provide you a outline on the drugs the don’t mix through antidepressants. However, some physicians leave this research up to the patient. The problem is that many people don’t actually perform the important research. That’s why we’ve placed together this “mixing drugs guide”. It’s our intention to rundown the details you have to know around mixing medication for depression with various other drugs.

What space Antidepressants?

When talking about antidepressants, we’re talking about a couple of specific class of drugs. They room as follows:


These drugs rise the amount of serotonin and also norepinephrine in the brain. Both of these chemicals pat a vital role in your mood, which is why SNRIs can be provided to treat the atmosphere disorders favor depression and anxiety. Other medications and also recreational drugs also raise serotonin and norepinephrine level in the brain. Acquisition those medicine can reason problems because that someone who already has SNRIs in your system.

Common SNRIs include:Desvenlafaxine (Pristiq)Venlafaxine (Effexor)Duloxetine (Cymbalta)


SSRIs occupational to regulate the amount of serotonin in our brain. Return serotonin is partly responsible for our ability to feeling happy, too much of it deserve to be a bad thing. Mixing SSRIs with other serotonin-boosting medicine can cause physical and also psychological troubles for the user. Common SSRIs include:

Citalopram (Celexa)Sertraline (Zoloft)Fluoxetine (Prozac)Escitalopram (Lexapro)Fluvoxamine (Luvox)Paroxetine (Paxil)


TCA antidepressants are prescribed much less than they supplied to be. This is due, in part, come the fact that they have an ext side impacts than SSRIs. Comparable to other medications for depression, however, they manage the serotonin bicycle in the brain. Together a result, lock can reason an overflow that serotonin if combined with particular substances. Common TCAs include:

Protriptyline (Vivactil)Desipramine (Norpramin)Trimipramine (Surmontil)


MAOIs don’t target the manufacturing or re-uptake that serotonin in the same means that other antidepressants do. They in reality target an enzyme in our body referred to as “monoamine oxidase”. This is the enzyme that division serotonin down. By reduce the amount of the enzyme, MAOIs enable the brain to receive much more serotonin 보다 it would certainly otherwise. MAOIs space not prescribed as regularly as they offered to be. Among the factors for this is that monoamine oxidase is kind of necessary for our bodies. It helps to flush out the undesirable chemicals that space often uncovered in alcohol and also other drugs. If someone drinks alcohol or supplies drugs while prescribed come MAOIs, their body might not be able to break it down. This can have severe negative consequences. The MAOI class includes:

Phenelzine (Nardil)Isocarboxazid (Marplan)Tranylcypromine (Parnate)Selegiline (Emsam)

Mixing Anti-Depression Pills with various other Drugs

If you take it antidepressants, over there are specific substances you need to avoid, yet many might not be mindful of them. In fact, the list of drugs the don’t mix through antidepressants may seem extensive, however there are an essential factors the are necessary to consider. The drugs outlined in this article can have actually dangerous consequences when mixed with depression meds. The is essential to remember that “mixing” doesn’t necessarily typical using both substances in ~ the very same time. Drugs will connect with the other substances that you already have in your body. If you take Prozac, for example, you will certainly accumulate the drug in her blood, liver and also other organs over time. Therefore, you do not do it take any drugs that have an unfavorable interactions v Prozac until you are sure it has been flushed out the your device entirely. Below are a few drugs the you need to never mix v antidepressants:

1. Never ever Do Coke when on Antidepressants


People who are prescribed pills for depression shouldn’t use cocaine. Period. Essentially, antidepressants are supplied to exactly chemical discrepancies within the brain. Our bodies develop chemicals that are sent to our brains in order to aid us feeling happy. These chemicals encompass serotonin and also dopamine. Once the brain receives too lot or too little of this chemicals, depression can occur. Anti-depression pills job-related to make certain we have actually the appropriate amount of serotonin and dopamine in our brain at all times. Cocaine, ~ above the other hand, causes sends a whole lot the serotonin come our mind all at once. This is why human being like it. The rush of serotonin provides them feel euphoric for a couple of minutes. Once someone mixes coke and also antidepressants in ~ the very same time, however, things can acquire dangerous. Mixing cocaine v antidepressants is risky because it can reason “serotonin syndrome”.

What is Serotonin Syndrome?

Serotonin syndrome happens once the body receives much more serotonin than it deserve to handle in ~ one time. The symptoms the serotonin syndrome usually include:


Both coke and also antidepressants can cause serotonin syndrome by themselves. However, the likelihood that this rises when castle are used in combination with one another.

2. Prevent Mixing Antidepressants and Alcohol

Among the list of drugs that don’t mix v antidepressants is alcohol. Doctors and manufacturers strongly recommend patients not to drink alcohol while taking antidepressants. Someone who drinks consistently while prescribed medication because that depression is likely to uncover that the drug does not boost their the atmosphere or psychological state and also is far better off abstaining indigenous booze. Additionally, drinking alcohol when on antidepressants can be downright dangerous.


The health risks vary depending upon which medicine the separation, personal, instance is prescribed: SSRIs: People who take SRRIs do not do it drink alcohol because that a variety of reasons. Drinking while on Lexapro, Celexa or Zoloft no deadly for most people. However, the can reason extreme drowsiness and also increase the threat of a blackout. Fluoxetine: Drinking while on Prozac (and other SSRIs the contain fluoxetine) is particularly dangerous. Mix Prozac and alcohol deserve to increase the user’s love rate and blood press to unsafe levels. The can likewise make depression lot worse if done regularly. MAOIs: It is highly advised no to drink booze if you’re taking an MAOI antidepressant. These drugs stop the human body from breaking under an enzyme dubbed tyramine. Too lot tyramine deserve to have a an unfavorable effect on ours heart, blood and other components of the body. Unfortunately, over there is a lot of tyramine in alcohol. As a result, mix MAOIs v alcohol can reason a spike in love rate and also blood pressure. This have the right to lead to irreversible heart problems and increased danger of heart attack. On optimal of this, the mixture have the right to lead come serotonin syndrome. TCAs: Particularly beforehand in your prescription, TCA users room advised not to drink at all. The key reason because that this is the the mixture can cause the separation, personal, instance to acquire drunk much much faster than they would normally. This

can greatly increase the danger of a blackout.

Are there Alcohol-Safe Meds for Depression?

Unfortunately, antidepressants perform not market the same mental benefits if girlfriend drink alcohol. People who are on medication for depression should abstain from drinking if they desire the medicine to have actually an optimal effect.

3. The risks of combining MDMA and SSRIs

The relationship in between MDMA (commonly well-known as “Molly”) and antidepressants is quite interesting. Civilization who take Molly frequently use SSRIs to combat the hangover they feeling for a few days afterward. Essentially, MDMA spikes the serotonin and also dopamine level in a person’s brain. This permits them to feel euphoric for several hours. As soon as the medicine wears off, your neurotransmitter levels drop far lower 보다 they to be beforehand. Antidepressants are offered in a strategic effort to regain serotonin levels earlier to normal. In countless cases, this works. However, those who use Molly and also antidepressants at the same time put themselves at risk of serotonin syndrome. Since MDMA skyrockets the level of serotonin and dopamine in the user’s brain, lock can enter shock and have seizures.

Taking Molly while on Antidepressants

MDMA and also antidepressants are a particularly dangerous cocktail for human being who room prescribed come SSRIs. Together Zoloft, Lexapro or Prozac and their byproducts accumulate in the user’s system over time, they occupational to regulate the quantity of serotonin that can reach the brain. These drugs work for depression due to the fact that they prevent any influx the serotonin from rushing in. When using MDMA, then, an individual on antidepressants might find the they don’t gain high. They might take too much Molly in the effort to feeling its effects. This is where points can obtain dangerous, as the user can flood their mind with serotonin. In the initiative to feel the results of Molly, some civilization end up taking also much. This deserve to potentially cause an overdose.

4. Part Cough medications Don’t Mix through Depression Meds

One that the reasons why MAOIs are prescribed much much less these work is that they have actually adverse reactions to a number of other usual drugs. If an MAO inhibitor is combined with drugs like Alka-Seltzer and Dayquil, because that example, the user will uncover that they get very drowsy an extremely quickly. This have the right to be specifically dangerous if the user is steering or requirements to operate hefty machinery. SSRIs, as well, have the right to have an adverse interactions v over-the-counter cough and also cold medications. Sertraline and citalopram, because that example, don’t mix v anti-inflammatory medications. While the combination may not kill you, mix Lexapro,

Prozac or Zoloft with aspirin have the right to take a pretty significant toll on your liver. Because the liver is the location where SSRIs room processed, throw anti-inflammatory drugs right into the mix can reason it to work far harder 보다 it need to be. Over time, this deserve to lead come liver damage, disease, and internal bleeding.

Do I have to Stop taking Cough medication if ns on Antidepressants?

There space literally hundreds of cold and cough meds that deserve to be purchased over the respond to at any kind of pharmacy. Some of them will respond adversely if supplied in conjunction v antidepressants. However, some medicines are perfectly safe to take. If she prescribed come Prozac, Celexa or any other medication because that depression, you deserve to use this drug interactions checker to make certain that you in any danger.

Can girlfriend Skip a dose to usage Drugs?

When it comes to recreational drug use, some world wonder if they can skip your antidepressant dose or avoid taking it because that a if if they want to acquire high. There are a few reasons why this gift a problem. Firstly, SSRIs and other mood-stabilizers space able to take effect because they are used regularly over a fairly long period of time. This is why most doctors prescribe antidepressants for number of months. Oftentimes, someone who battles with depression won’t

start to notice the impacts of your prescription because that at the very least a couple of weeks. This timeframe will rise if the human uses various other drugs or drink alcohol. The will likewise increase if they skip dosages. Doing so is basically erasing several of the work that your antidepressants have currently done. People frequently forget the antidepressants are intended to have actually long-lasting impacts in the brain. Unlike cocaine, SSRIs and other depression meds have actually a fairly long lifespan in the body. This means that the drug and its byproducts live in your

system for months, an especially if you take them on a constant basis.

Therefore, just since you skip one sheep doesn’t median you must start mixing other drugs with the antidepressants you’ve accumulated in your system.

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Be Aware: Drugs that Don’t Mix with Antidepressants

Mixing antidepressants v alcohol, cocaine, Molly or other illegal drugs is never ever recommended. If you’re acquisition medication because that depression, that is necessary that you leaving the medicine alone and don’t throw in any kind of other building material that might prevent it from act its job. If you do should take extr prescriptions or medications, make certain to top a doctor or professional drug specialist first. They’ll have the ability to advise friend on i beg your pardon drugs have the right to be safely combined with her antidepressant.