Medically the evaluation by Darren Hein, PharmD — composed by university of Illinois — update on September 2, 2018


Mucinex and Nyquil Cold & Flu space two common, over-the-counter remedies girlfriend can find on her pharmacist’s shelf. To compare the symptoms that each medicine treats and their next effects, interactions, and also warnings to view if one is a far better option because that you.

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The key differences between these drugs space their energetic ingredients and how those job-related to treat her symptoms.

Mucinex treats chest congestion. The main active ingredient is an expectorant dubbed guaifenesin. It works by thinning the consistency of rubber in your air passages. This loosens up rubber in her chest so you can cough that up and also out.

NyQuil temporary treats typical cold and flu symptoms such as fever, cough, sleep congestion, boy aches and also pains, headache, and runny nose and sneezing. The active ingredients room acetaminophen, dextromethorphan, and doxylamine. These ingredients each work-related a tiny differently.

For example, paracetamol is a pain reliever and fever reducer. It alters the way your human body senses pain and regulates temperature. Dextromethorphan suppresses the signal in your mind that cause your coughing reflex. Doxylamine, on the other hand, block a substance in your body called histamine. This substance reasons allergy symptom such as itchy, watery eyes, runny nose, and itchy nose or throat. Together, this ingredients administer the relief friend can obtain from NyQuil.

The adhering to table summarizes the differences in between Mucinex and NyQuil in ~ a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, sleep congestion, young aches and pains, headache, sick throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, dental granulesoral fluid capsule, dental solution
Risk the interactionsnoyes
Risk of severe side effectsnoyes

*There is also an extra-strength type of this tablet, which includes twice as lot of the active ingredient.

Forms and also dosage

You can use Mucinex transparent the day, however you generally use NyQuil at night to assist you sleep and also let your body recover. The ingredient doxylamine in NyQuil additionally causes drowsiness to assist you obtain rest.

Mucinex and also NyQuil Cold & Flu are just for human being 12 years and older. However, NyQuil has other commodities that are specifically made for youngsters ages 4 come 11 years.

The recommended dosage for each drug varies according to the form. Follow the recommended dosage top top the package of whatever kind you choose. Friend will must ask your medical professional for the exactly dosage of NyQuil to offer to kids who room 4 to 11 year old.

Mucinex go not have the risk of major side effects. However, the adhering to serious side results may be possible with NyQuil:

vision problems, such together blurry visiondifficulty urinatingallergic reaction, with symptoms such as:red, peeling or blistering skinrashhivesitchingswelling that the face, throat, tongue, lips, eyes, hands, or reduced legsdifficulty breath or swallowing

If you have serious next effects, you need to stop making use of the drug and call your doctor.


Drug interactions have the right to increase or to decrease the impact of the other medications. Interaction can also increase your danger of next effects. There room no known far-reaching interactions v guaifenesin, the energetic ingredient in Mucinex. However, all three energetic ingredients that NyQuil communicate with other drugs.

Acetaminophen can connect with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can connect with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can communicate with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such together fentanyl, hydrocodone, methadone, and also morphine

You shouldn’t use Mucinex or NyQuil come treat a permanent cough. Making use of too lot can cause harmful effects. You also shouldn’t usage these products to treat symptoms of any type of medical problem you have actually without talking to your medical professional first.

Other conditions

Other problems you may have actually can affect how NyQuil functions for you. In some conditions, this drug can be harmful. Asking a doctor prior to using NyQuil if you have:

liver diseaseglaucomaurinating because of enlarged prostate gland


Don’t use Mucinex or NyQuil for longer than seven days. If her symptoms no relieved after a week, contact your doctor and also stop making use of these drugs.

NyQuil has acetaminophen, which deserve to cause far-reaching liver damage if girlfriend overuse it. Taking an ext than 4 doses of NyQuil in 24 hours can reason severe liver damage. Many over-the-counter drugs additionally contain acetaminophen. If you take it NyQuil, make certain you don’t take it it with various other drugs that contain acetaminophen. This will assist make sure you don’t accidentally usage too much of the drug.

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Mucinex and also NyQuil are both commodities that relax symptoms that the usual cold or flu. The symptoms they treat are different. You can take Mucinex and NyQuil with each other safely if you monitor the recommended dosage because that each drug. However, acquisition Mucinex in ~ night through NyQuil might actually store you native falling asleep. Mucinex will certainly loosen her mucus, i beg your pardon can cause you come wake up to cough.

Deciding between the two may simply mean picking the medicine that treats the symptom that room bothering girlfriend the most. The course, you have to never take any drug if you’re not sure just how to use it or if it’s ideal for you. Constantly talk come your medical professional if you have questions.