Diphenhydramine as an adjunct come sedation for colonoscopy: a double-blind randomized, placebo-controlled study
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Intravenous benzodiazepines in combination with opiates are used to attain moderate sedation because that colonoscopy. Return effective, this agents have actually potential adverse effects, such as respiratory depression and also hypotension. Diphenhydramine hydrochloride possesses main nervous system depressant effects that theoretically could administer a synergistic impact for sedating patients.

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The objective was to assess the efficacy of adding diphenhydramine hydrochloride as an adjunct to enhance sedation and to mitigate the quantity of traditional sedatives used during colonoscopy.
The research group comprised 270 patient undergoing screening/diagnostic/therapeutic colonoscopy were enrolled.
Patients were randomized to get either 50 mg that diphenhydramine or placebo, provided intravenously 3 minutes before starting conscious sedation v intravenous midazolam and meperidine.
The main outcome measure up was anesthetic impact as assessed by the endoscopy team and also by the patient; quantity of adjunctive sedatives to accomplish adequate sedation.
Of 270 patients, data to be analyzed for 258 patients, through 130 patients in the diphenhydramine group and 128 patients in the placebo group. There to be a 10.1% palliation in meperidine usage and 13.7% reduction in midazolam consumption in favor of the diphenhydramine group. The median evaluation scores as judged through the faculty, the fellows, and the nurses were statistically significant in favor of the diphenhydramine group. In addition, patience scores for as whole sedation and also pain level favored the team that received diphenhydramine.
Intravenous diphenhydramine given before initiation of standard sedation uses a significant benefit to conscious sedation for patients experience colonoscopy.
in: Hardman J.G. Limbird L.E. Goodman and Gilman"s the pharmacological basis of therapeutics. 10th ed. McGraw-Hill, new York2001: 651-657
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